Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome
Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.
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Nature Portfolio
2018
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| Acceso en línea: | https://doaj.org/article/b33496fa8a17473f945f0a89142ec415 |
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oai:doaj.org-article:b33496fa8a17473f945f0a89142ec4152021-12-02T17:32:01ZTargeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome10.1038/s41467-018-03770-32041-1723https://doaj.org/article/b33496fa8a17473f945f0a89142ec4152018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03770-3https://doaj.org/toc/2041-1723Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.Gabriel BalmusDelphine LarrieuAna C. BarrosCasey CollinsMonica AbrudanMukerrem DemirNicola J. GeislerChristopher J. LelliottJacqueline K. WhiteNatasha A. KarpJames AtkinsonAndrea KirtonMatt JacobsenDean CliftRaphael RodriguezSanger Mouse Genetics ProjectDavid J. AdamsStephen P. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Gabriel Balmus Delphine Larrieu Ana C. Barros Casey Collins Monica Abrudan Mukerrem Demir Nicola J. Geisler Christopher J. Lelliott Jacqueline K. White Natasha A. Karp James Atkinson Andrea Kirton Matt Jacobsen Dean Clift Raphael Rodriguez Sanger Mouse Genetics Project David J. Adams Stephen P. Jackson Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome |
| description |
Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging. |
| format |
article |
| author |
Gabriel Balmus Delphine Larrieu Ana C. Barros Casey Collins Monica Abrudan Mukerrem Demir Nicola J. Geisler Christopher J. Lelliott Jacqueline K. White Natasha A. Karp James Atkinson Andrea Kirton Matt Jacobsen Dean Clift Raphael Rodriguez Sanger Mouse Genetics Project David J. Adams Stephen P. Jackson |
| author_facet |
Gabriel Balmus Delphine Larrieu Ana C. Barros Casey Collins Monica Abrudan Mukerrem Demir Nicola J. Geisler Christopher J. Lelliott Jacqueline K. White Natasha A. Karp James Atkinson Andrea Kirton Matt Jacobsen Dean Clift Raphael Rodriguez Sanger Mouse Genetics Project David J. Adams Stephen P. Jackson |
| author_sort |
Gabriel Balmus |
| title |
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome |
| title_short |
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome |
| title_full |
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome |
| title_fullStr |
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome |
| title_full_unstemmed |
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome |
| title_sort |
targeting of nat10 enhances healthspan in a mouse model of human accelerated aging syndrome |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/b33496fa8a17473f945f0a89142ec415 |
| work_keys_str_mv |
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1718380450188099584 |