Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome
Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-related phenotypes in a mouse model of premature aging.
Guardado en:
Autores principales: | Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b33496fa8a17473f945f0a89142ec415 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Robust and sensitive analysis of mouse knockout phenotypes.
por: Natasha A Karp, et al.
Publicado: (2012) -
Longevity leap: mind the healthspan gap
por: Armin Garmany, et al.
Publicado: (2021) -
Bacterial processing of glucose modulates C. elegans lifespan and healthspan
por: Samuel F. Kingsley, et al.
Publicado: (2021) -
Confessions of Nat Turner
por: Nat Turner
Publicado: (2009) -
G6PD protects from oxidative damage and improves healthspan in mice
por: Sandrina Nóbrega-Pereira, et al.
Publicado: (2016)