X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conformation which is a key intermediate in the LeuT trans...

Full description

Saved in:
Bibliographic Details
Main Authors: Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1

Similar Items