X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conformation which is a key intermediate in the LeuT trans...

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Autores principales:	Kamil Gotfryd, Thomas Boesen, Jonas S. Mortensen, George Khelashvili, Matthias Quick, Daniel S. Terry, Julie W. Missel, Michael V. LeVine, Pontus Gourdon, Scott C. Blanchard, Jonathan A. Javitch, Harel Weinstein, Claus J. Loland, Poul Nissen, Ulrik Gether
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1
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spelling	oai:doaj.org-article:b7943f31d4e74b9daf78fc8c7d1b60c12021-12-02T15:39:18ZX-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release10.1038/s41467-020-14735-w2041-1723https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c12020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14735-whttps://doaj.org/toc/2041-1723Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conformation which is a key intermediate in the LeuT transport cycle.Kamil GotfrydThomas BoesenJonas S. MortensenGeorge KhelashviliMatthias QuickDaniel S. TerryJulie W. MisselMichael V. LeVinePontus GourdonScott C. BlanchardJonathan A. JavitchHarel WeinsteinClaus J. LolandPoul NissenUlrik GetherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kamil Gotfryd Thomas Boesen Jonas S. Mortensen George Khelashvili Matthias Quick Daniel S. Terry Julie W. Missel Michael V. LeVine Pontus Gourdon Scott C. Blanchard Jonathan A. Javitch Harel Weinstein Claus J. Loland Poul Nissen Ulrik Gether X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
description	Neurotransmitter:sodium symporters (NSS) serve as targets for drugs including antidepressants and psychostimulants. Here authors report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na+/substrate-bound, inward-facing occluded conformation which is a key intermediate in the LeuT transport cycle.
format	article
author	Kamil Gotfryd Thomas Boesen Jonas S. Mortensen George Khelashvili Matthias Quick Daniel S. Terry Julie W. Missel Michael V. LeVine Pontus Gourdon Scott C. Blanchard Jonathan A. Javitch Harel Weinstein Claus J. Loland Poul Nissen Ulrik Gether
author_facet	Kamil Gotfryd Thomas Boesen Jonas S. Mortensen George Khelashvili Matthias Quick Daniel S. Terry Julie W. Missel Michael V. LeVine Pontus Gourdon Scott C. Blanchard Jonathan A. Javitch Harel Weinstein Claus J. Loland Poul Nissen Ulrik Gether
author_sort	Kamil Gotfryd
title	X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
title_short	X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
title_full	X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
title_fullStr	X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
title_full_unstemmed	X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release
title_sort	x-ray structure of leut in an inward-facing occluded conformation reveals mechanism of substrate release
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b7943f31d4e74b9daf78fc8c7d1b60c1
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X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

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