Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes

Plasticity and clonal population structure in bacterial genomes can hinder traditional SNP-based genetic association studies. Here, Corander and colleagues present a method to identify variable-length sequence elements enriched in a phenotype of interest, and demonstrate its use in human pathogens.

Guardado en:

Detalles Bibliográficos
Autores principales:	John A. Lees, Minna Vehkala, Niko Välimäki, Simon R. Harris, Claire Chewapreecha, Nicholas J. Croucher, Pekka Marttinen, Mark R. Davies, Andrew C. Steer, Steven Y. C. Tong, Antti Honkela, Julian Parkhill, Stephen D. Bentley, Jukka Corander
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cf0152cd3fa84f69ab1a6244a1daed1f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cf0152cd3fa84f69ab1a6244a1daed1f
record_format	dspace
spelling	oai:doaj.org-article:cf0152cd3fa84f69ab1a6244a1daed1f2021-12-02T16:57:05ZSequence element enrichment analysis to determine the genetic basis of bacterial phenotypes10.1038/ncomms127972041-1723https://doaj.org/article/cf0152cd3fa84f69ab1a6244a1daed1f2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12797https://doaj.org/toc/2041-1723Plasticity and clonal population structure in bacterial genomes can hinder traditional SNP-based genetic association studies. Here, Corander and colleagues present a method to identify variable-length sequence elements enriched in a phenotype of interest, and demonstrate its use in human pathogens.John A. LeesMinna VehkalaNiko VälimäkiSimon R. HarrisClaire ChewapreechaNicholas J. CroucherPekka MarttinenMark R. DaviesAndrew C. SteerSteven Y. C. TongAntti HonkelaJulian ParkhillStephen D. BentleyJukka CoranderNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John A. Lees Minna Vehkala Niko Välimäki Simon R. Harris Claire Chewapreecha Nicholas J. Croucher Pekka Marttinen Mark R. Davies Andrew C. Steer Steven Y. C. Tong Antti Honkela Julian Parkhill Stephen D. Bentley Jukka Corander Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
description	Plasticity and clonal population structure in bacterial genomes can hinder traditional SNP-based genetic association studies. Here, Corander and colleagues present a method to identify variable-length sequence elements enriched in a phenotype of interest, and demonstrate its use in human pathogens.
format	article
author	John A. Lees Minna Vehkala Niko Välimäki Simon R. Harris Claire Chewapreecha Nicholas J. Croucher Pekka Marttinen Mark R. Davies Andrew C. Steer Steven Y. C. Tong Antti Honkela Julian Parkhill Stephen D. Bentley Jukka Corander
author_facet	John A. Lees Minna Vehkala Niko Välimäki Simon R. Harris Claire Chewapreecha Nicholas J. Croucher Pekka Marttinen Mark R. Davies Andrew C. Steer Steven Y. C. Tong Antti Honkela Julian Parkhill Stephen D. Bentley Jukka Corander
author_sort	John A. Lees
title	Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
title_short	Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
title_full	Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
title_fullStr	Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
title_full_unstemmed	Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
title_sort	sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cf0152cd3fa84f69ab1a6244a1daed1f
work_keys_str_mv	AT johnalees sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT minnavehkala sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT nikovalimaki sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT simonrharris sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT clairechewapreecha sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT nicholasjcroucher sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT pekkamarttinen sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT markrdavies sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT andrewcsteer sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT stevenyctong sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT anttihonkela sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT julianparkhill sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT stephendbentley sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes AT jukkacorander sequenceelementenrichmentanalysistodeterminethegeneticbasisofbacterialphenotypes
_version_	1718382648381931520

Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes

Ejemplares similares