Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse

How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 control...

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Autores principales: Anna D. Senft, Elizabeth K. Bikoff, Elizabeth J. Robertson, Ita Costello
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d165dcef375f4774be02535361889157
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spelling oai:doaj.org-article:d165dcef375f4774be025353618891572021-12-02T16:57:09ZGenetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse10.1038/s41467-019-09052-w2041-1723https://doaj.org/article/d165dcef375f4774be025353618891572019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09052-whttps://doaj.org/toc/2041-1723How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 controls PGC migration.Anna D. SenftElizabeth K. BikoffElizabeth J. RobertsonIta CostelloNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Anna D. Senft
Elizabeth K. Bikoff
Elizabeth J. Robertson
Ita Costello
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
description How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 controls PGC migration.
format article
author Anna D. Senft
Elizabeth K. Bikoff
Elizabeth J. Robertson
Ita Costello
author_facet Anna D. Senft
Elizabeth K. Bikoff
Elizabeth J. Robertson
Ita Costello
author_sort Anna D. Senft
title Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
title_short Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
title_full Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
title_fullStr Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
title_full_unstemmed Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
title_sort genetic dissection of nodal and bmp signalling requirements during primordial germ cell development in mouse
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d165dcef375f4774be02535361889157
work_keys_str_mv AT annadsenft geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse
AT elizabethkbikoff geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse
AT elizabethjrobertson geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse
AT itacostello geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse
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