Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse
How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 control...
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Nature Portfolio
2019
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oai:doaj.org-article:d165dcef375f4774be025353618891572021-12-02T16:57:09ZGenetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse10.1038/s41467-019-09052-w2041-1723https://doaj.org/article/d165dcef375f4774be025353618891572019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09052-whttps://doaj.org/toc/2041-1723How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 controls PGC migration.Anna D. SenftElizabeth K. BikoffElizabeth J. RobertsonIta CostelloNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
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Science Q Anna D. Senft Elizabeth K. Bikoff Elizabeth J. Robertson Ita Costello Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse |
description |
How Nodal and Bmp pathways interact during primordial germ cell (PGC) formation remains unclear. Here, the authors show Nodal signalling via Eomes in the epiblast, together with Smad2 in the visceral endoderm, regulates formation of the mouse PGC lineage, while Smad1 specifies PGCs and Smad4 controls PGC migration. |
format |
article |
author |
Anna D. Senft Elizabeth K. Bikoff Elizabeth J. Robertson Ita Costello |
author_facet |
Anna D. Senft Elizabeth K. Bikoff Elizabeth J. Robertson Ita Costello |
author_sort |
Anna D. Senft |
title |
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse |
title_short |
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse |
title_full |
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse |
title_fullStr |
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse |
title_full_unstemmed |
Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse |
title_sort |
genetic dissection of nodal and bmp signalling requirements during primordial germ cell development in mouse |
publisher |
Nature Portfolio |
publishDate |
2019 |
url |
https://doaj.org/article/d165dcef375f4774be02535361889157 |
work_keys_str_mv |
AT annadsenft geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse AT elizabethkbikoff geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse AT elizabethjrobertson geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse AT itacostello geneticdissectionofnodalandbmpsignallingrequirementsduringprimordialgermcelldevelopmentinmouse |
_version_ |
1718382648751030272 |