Rescue of conformational dynamics in enzyme catalysis by directed evolution

par Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James S. Fraser
Publié 2018

Directed evolution of CRISPR-Cas9 to increase its specificity

par Jungjoon K. Lee, Euihwan Jeong, Joonsun Lee, Minhee Jung, Eunji Shin, Young-hoon Kim, Kangin Lee, Inyoung Jung, Daesik Kim, Seokjoong Kim, Jin-Soo Kim
Publié 2018

Robust and flexible platform for directed evolution of yeast genetic switches

par Masahiro Tominaga, Kenta Nozaki, Daisuke Umeno, Jun Ishii, Akihiko Kondo
Publié 2021

A roadmap to directed enzyme evolution and screening systems for biotechnological applications

par Martínez,Ronny, Schwaneberg,Ulrich
Publié 2013

UMI-linked consensus sequencing enables phylogenetic analysis of directed evolution

par Paul Jannis Zurek, Philipp Knyphausen, Katharina Neufeld, Ahir Pushpanath, Florian Hollfelder
Publié 2020

Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance

par Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni
Publié 2018

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis

par Alessandro Angelini, Yoshishige Miyabe, Daniel Newsted, Byron H. Kwan, Chie Miyabe, Ryan L. Kelly, Misha N. Jamy, Andrew D. Luster, K. Dane Wittrup
Publié 2018

Human cell based directed evolution of adenine base editors with improved efficiency

par Junhao Fu, Qing Li, Xiaoyu Liu, Tianxiang Tu, Xiujuan Lv, Xidi Yin, Jineng Lv, Zongming Song, Jia Qu, Jinwei Zhang, Jinsong Li, Feng Gu
Publié 2021

Directed evolution of rRNA improves translation kinetics and recombinant protein yield

par Fan Liu, Siniša Bratulić, Alan Costello, Teemu P. Miettinen, Ahmed H. Badran
Publié 2021

Multiplex suppression of four quadruplet codons via tRNA directed evolution

par Erika A. DeBenedictis, Gavriela D. Carver, Christina Z. Chung, Dieter Söll, Ahmed H. Badran
Publié 2021

Engineered dual selection for directed evolution of SpCas9 PAM specificity

par Gregory W. Goldberg, Jeffrey M. Spencer, David O. Giganti, Brendan R. Camellato, Neta Agmon, David M. Ichikawa, Jef D. Boeke, Marcus B. Noyes
Publié 2021

Directed evolution generates a novel oncolytic virus for the treatment of colon cancer.

par Irene Kuhn, Paul Harden, Maxine Bauzon, Cecile Chartier, Julie Nye, Steve Thorne, Tony Reid, Shaoheng Ni, Andre Lieber, Kerry Fisher, Len Seymour, Gabor M Rubanyi, Richard N Harkins, Terry W Hermiston
Publié 2008

Directed evolution of prenylated FMN-dependent Fdc supports efficient in vivo isobutene production

par Annica Saaret, Benoît Villiers, François Stricher, Macha Anissimova, Mélodie Cadillon, Reynard Spiess, Sam Hay, David Leys
Publié 2021

Directed evolution and secretory expression of xylose isomerase for improved utilisation of xylose in Saccharomyces cerevisiae

par Jung-Hoon Bae, Mi-Jin Kim, Bong Hyun Sung, Yong-Su Jin, Jung-Hoon Sohn
Publié 2021

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico

par Aron Broom, Rojo V. Rakotoharisoa, Michael C. Thompson, Niayesh Zarifi, Erin Nguyen, Nurzhan Mukhametzhanov, Lin Liu, James S. Fraser, Roberto A. Chica
Publié 2020

Directed evolution of an LBP/CD14 inhibitory peptide and its anti-endotoxin activity.

par Li Fang, Zhi Xu, Guan-song Wang, Fu-yun Ji, Chun-xia Mei, Juan Liu, Guo-ming Wu
Publié 2014

Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex

par Luke F. Pennington, Pascal Gasser, Silke Kleinboelting, Chensong Zhang, Georgios Skiniotis, Alexander Eggel, Theodore S. Jardetzky
Publié 2021

Improved pyrrolysine biosynthesis through phage assisted non-continuous directed evolution of the complete pathway

par Joanne M. L. Ho, Corwin A. Miller, Kathryn A. Smith, Jacob R. Mattia, Matthew R. Bennett
Publié 2021

Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes

par Hoang Long Pham, Adison Wong, Niying Chua, Wei Suong Teo, Wen Shan Yew, Matthew Wook Chang
Publié 2017

A thermostable β-glucuronidase obtained by directed evolution as a reporter gene in transgenic plants.

par Ai-Sheng Xiong, Ri-He Peng, Jing Zhuang, Jian-Min Chen, Bin Zhang, Jian Zhang, Quan-Hong Yao
Publié 2011