Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

por Yasuaki Kabe, Takanori Nakane, Ikko Koike, Tatsuya Yamamoto, Yuki Sugiura, Erisa Harada, Kenji Sugase, Tatsuro Shimamura, Mitsuyo Ohmura, Kazumi Muraoka, Ayumi Yamamoto, Takeshi Uchida, So Iwata, Yuki Yamaguchi, Elena Krayukhina, Masanori Noda, Hiroshi Handa, Koichiro Ishimori, Susumu Uchiyama, Takuya Kobayashi, Makoto Suematsu
Publicado 2016

An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer

por Rajdeep Das, Martin Sjöström, Raunak Shrestha, Christopher Yogodzinski, Emily A. Egusa, Lisa N. Chesner, William S. Chen, Jonathan Chou, Donna K. Dang, Jason T. Swinderman, Alex Ge, Junjie T. Hua, Shaheen Kabir, David A. Quigley, Eric J. Small, Alan Ashworth, Felix Y. Feng, Luke A. Gilbert
Publicado 2021

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

por Xiaozhen Zhang, Xing Huang, Jian Xu, Enliang Li, Mengyi Lao, Tianyu Tang, Gang Zhang, Chengxiang Guo, Xiaoyu Zhang, Wen Chen, Dipesh Kumar Yadav, Xueli Bai, Tingbo Liang
Publicado 2021

Preparation of multifunctional nanobubbles and their application in bimodal imaging and targeted combination therapy of early pancreatic cancer

por Hengli Yang, Ping Zhao, Yonggang Zhou, Qiaoying Li, Wenbin Cai, Zongxia Zhao, Jian Shen, Kechun Yao, Yunyou Duan
Publicado 2021

Treatment-related amenorrhea in a modern, prospective cohort study of young women with breast cancer

por Philip D. Poorvu, Jiani Hu, Yue Zheng, Shari I. Gelber, Kathryn J. Ruddy, Rulla M. Tamimi, Jeffrey M. Peppercorn, Lidia Schapira, Virginia F. Borges, Steven E. Come, Ellen Warner, Matteo Lambertini, Shoshana M. Rosenberg, Ann H. Partridge
Publicado 2021

Outcomes of changing systemic therapy in patients with relapsed breast cancer and 1 to 3 brain metastases

por Omar Alhalabi, Zaid Soomro, Ryan Sun, Elshad Hasanov, Aya Albittar, Debu Tripathy, Vicente Valero, Nuhad K. Ibrahim
Publicado 2021

Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models

por Hyoung Kim, Haineng Xu, Erin George, Dorothy Hallberg, Sushil Kumar, Veena Jagannathan, Sergey Medvedev, Yasuto Kinose, Kyle Devins, Priyanka Verma, Kevin Ly, Yifan Wang, Roger A. Greenberg, Lauren Schwartz, Neil Johnson, Robert B. Scharpf, Gordon B. Mills, Rugang Zhang, Victor E. Velculescu, Eric J. Brown, Fiona Simpkins
Publicado 2020

Abdominal FLASH irradiation reduces radiation-induced gastrointestinal toxicity for the treatment of ovarian cancer in mice

por Karen Levy, Suchitra Natarajan, Jinghui Wang, Stephanie Chow, Joshua T. Eggold, Phoebe E. Loo, Rakesh Manjappa, Stavros Melemenidis, Frederick M. Lartey, Emil Schüler, Lawrie Skinner, Marjan Rafat, Ryan Ko, Anna Kim, Duaa H. Al-Rawi, Rie von Eyben, Oliver Dorigo, Kerriann M. Casey, Edward E. Graves, Karl Bush, Amy S. Yu, Albert C. Koong, Peter G. Maxim, Billy W. Loo, Erinn B. Rankin
Publicado 2020

Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer

por Yundong He, Shihong Peng, Jinhua Wang, Huang Chen, Xiaonan Cong, Ang Chen, Meichun Hu, Min Qin, Haigang Wu, Shuman Gao, Liguo Wang, Xin Wang, Zhengfang Yi, Mingyao Liu
Publicado 2016

Clinical cancer genomic profiling by three-platform sequencing of whole genome, whole exome and transcriptome

por Michael Rusch, Joy Nakitandwe, Sheila Shurtleff, Scott Newman, Zhaojie Zhang, Michael N. Edmonson, Matthew Parker, Yuannian Jiao, Xiaotu Ma, Yanling Liu, Jiali Gu, Michael F. Walsh, Jared Becksfort, Andrew Thrasher, Yongjin Li, James McMurry, Erin Hedlund, Aman Patel, John Easton, Donald Yergeau, Bhavin Vadodaria, Ruth G. Tatevossian, Susana Raimondi, Dale Hedges, Xiang Chen, Kohei Hagiwara, Rose McGee, Giles W. Robinson, Jeffery M. Klco, Tanja A. Gruber, David W. Ellison, James R Downing, Jinghui Zhang
Publicado 2018

Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy

por Hayley C. Affronti, Aryn M. Rowsam, Anthony J. Pellerite, Spencer R. Rosario, Mark D. Long, Justine J. Jacobi, Anna Bianchi-Smiraglia, Christoph S. Boerlin, Bryan M. Gillard, Ellen Karasik, Barbara A. Foster, Michael Moser, John H. Wilton, Kristopher Attwood, Mikhail A. Nikiforov, Gissou Azabdaftari, Roberto Pili, James G. Phillips, Robert A. Casero, Dominic J. Smiraglia
Publicado 2020

A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer

por Tao Zhang, Jingjie Li, Yuan He, Feifei Yang, Yun Hao, Wangrui Jin, Jing Wu, Zhenliang Sun, Yunqi Li, Yihua Chen, Zhengfang Yi, Mingyao Liu
Publicado 2018

A microRNA panel compared to environmental and polygenic scores for colorectal cancer risk prediction

por Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Feng Guo, Megha Bhardwaj, Kaya Miah, Petra Schrotz-King, Hermann Brenner
Publicado 2021

Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility

por Linda Kachuri, Mattias Johansson, Sara R. Rashkin, Rebecca E. Graff, Yohan Bossé, Venkata Manem, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Paolo Vineis, Geoffrey Liu, Ghislaine Scelo, David Zaridze, Sanjay S. Shete, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardón, Gad Rennert, Chu Chen, Gary E. Goodman, Jennifer A. Doherty, Heike Bickeböller, John K. Field, Michael P. Davies, M. Dawn Teare, Lambertus A. Kiemeney, Stig E. Bojesen, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Loïc Le Marchand, Iona Cheng, Matthew B. Schabath, Eric J. Duell, Angeline S. Andrew, Jonas Manjer, Philip Lazarus, Susanne Arnold, James D. McKay, Nima C. Emami, Matthew T. Warkentin, Yonathan Brhane, Ma’en Obeidat, Richard M. Martin, Caroline Relton, George Davey Smith, Philip C. Haycock, Christopher I. Amos, Paul Brennan, John S. Witte, Rayjean J. Hung
Publicado 2020

Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy

por Jonathan F. Anker, Anum F. Naseem, Hanlin Mok, Anthony J. Schaeffer, Sarki A. Abdulkadir, Praveen Thumbikat
Publicado 2018

Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

por Yongqing Liu, Laura Siles, Xiaoqin Lu, Kevin C. Dean, Miriam Cuatrecasas, Antonio Postigo, Douglas C. Dean
Publicado 2018

Combined bioinformatics technology to explore pivot genes and related clinical prognosis in the development of gastric cancer

por Jiasheng Xu, Xinlu Wang, Qiwen Ke, Kaili Liao, Yanhua Wan, Kaihua Zhang, Guanyu Zhang, Xiaozhong Wang
Publicado 2021

Circulating tumour cells at baseline and late phase of treatment provide prognostic value in breast cancer

por Shuyun Pang, Hanjun Li, Shu Xu, Liying Feng, Xueping Ma, Yanan Chu, Bingjie Zou, Shaohua Wang, Guohua Zhou
Publicado 2021

Molecular classification of breast cancer using the mRNA expression profiles of immune-related genes

por Juan Mei, Ji Zhao, Yi Fu
Publicado 2020

Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues

por Kotaro Hama, Yuko Fujiwara, Tamuro Hayama, Tsuyoshi Ozawa, Keijiro Nozawa, Keiji Matsuda, Yojiro Hashiguchi, Kazuaki Yokoyama
Publicado 2021