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  1. 6201
    Intratumoral heterogeneity and clonal evolution in liver cancer
    “...Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular...”
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  2. 6202
    Viral pathogens hitchhike with insect sperm for paternal transmission
    “...Arbovirus vertical transmission is commonly mediated by transovarial passage of female insect...”
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  3. 6203
    Metal-free alcohol-directed regioselective heteroarylation of remote unactivated C(sp3)–H bonds
    “.... Here, the authors report the C(sp3)-heteroaryl bond formation in aliphatic alcohols mediated by alkoxy...”
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  4. 6204
    A large modulation of electron-phonon coupling and an emergent superconducting dome in doped strong ferroelectrics
    por Jiaji Ma, Ruihan Yang, Hanghui Chen
    Publicado 2021
    “... across the structural phase transition and as a result, phonon-mediated superconductivity emerges....”
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  5. 6205
    Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
    “...Gasdermins mediate lytic cell death by forming pores in the plasma membrane. Here the authors show...”
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  6. 6206
    Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
    “...NAD+ is an important coenzyme that mediates cellular metabolism and defends against stresses due...”
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  7. 6207
    Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
    “... urothelium is unclear. Here, the authors show that PPAR gamma mediates urothelial development during both...”
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  8. 6208
    Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
    “..., the authors show that inhibition of PHGDH, which mediates the first step in the serine synthesis pathway...”
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  9. 6209
    Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
    “... regulatory T cells to mediate tolerance in a humanized mouse model....”
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  10. 6210
    Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer
    “... epigenetically mediated cell state transitions rather than sub population selection....”
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  11. 6211
    Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma
    “... in the resistance to chemotherapy and metastasis through activation of FAK-mediated signalling....”
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  12. 6212
    Crystal structure of the red light-activated channelrhodopsin Chrimson
    “...Channelrhodopsins are light-activated ion channels that mediate cation permeation across cell...”
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  13. 6213
    Advancing behavioural genomics by considering timescale
    “... expression mediate behavioural responses to the environment, a key question in behavioural genomics....”
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  14. 6214
    Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
    “... determinants of Piezo activation, providing mechanistic insights into Piezo-mediated mechanotransduction....”
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  15. 6215
    Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria
    “... mediated inhibition of end-joining....”
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  16. 6216
    Cadherin-11 localizes to focal adhesions and promotes cell–substrate adhesion
    “... through an undefined mechanism. Langhe et al.show that cadherin-11 mediates adhesion to the cell matrix...”
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  17. 6217
    Climate-human interaction associated with southeast Australian megafauna extinction patterns
    “... and find that water availability mediates the relationship among climate, human migration and megafauna...”
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  18. 6218
    Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy
    “...The presence of several biological barriers impede the efficacy of nano-mediated drug delivery...”
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  19. 6219
    Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation
    “... cell proteome, providing a resource to assess mechanistic constraints on acetylation-mediated protein...”
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  20. 6220
    CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling
    por Joon-Il Jun, Lester F. Lau
    Publicado 2020
    “... and an association with inflammation. Here, the authors identify a possible mechanism by showing that CCN1 mediates...”
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