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  1. 6521
    Humans and seasonal climate variability threaten large-bodied coral reef fish with small ranges
    “...Knowing which species traits may confer resilience to human-mediated stressors will help predict...”
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  2. 6522
    Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
    “...RIPK3-mediated phosphorylation of the mixed lineage kinase domain-like (MLKL) pseudokinase...”
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  3. 6523
    Nitrous oxide as a function of oxygen and archaeal gene abundance in the North Pacific
    “... greenhouse gas, is of critical importance. Here, the authors reveal an archaeal-mediated N2O production...”
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  4. 6524
    Structure of the human marker of self 5-transmembrane receptor CD47
    “...-length human CD47 and provide insights into the molecular mechanism of CD47-mediated signalling....”
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  5. 6525
    NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity
    “... and that enhancing Prlh-mediated neurotransmission from the NTS dampens hypothalamically-driven hyperphagia...”
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  6. 6526
    Cognition and inflammation: “the role of cytokines in cognitive performance”
    por Jorge Mauricio Cuartas Arias
    Publicado 2014
    “... carry out in the central nervous system (CNS), going from mediators of neuropathologic processes...”
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  7. 6527
    Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
    “... show that MeCP2 mediates the higher-order assembly of a large splicing complex Rbfox/LASR, which...”
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  8. 6528
    Tracking Microbial Evolution in the Subseafloor Biosphere
    por Rika E. Anderson
    Publicado 2021
    “..., bacteria, and viruses across a diversity of habitats. These microbes play key roles in mediating global...”
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  9. 6529
    Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide
    “.... The reported data, including crystal structure of the 5-hydroxythalidomide-mediated complex of CRBN with SALL4...”
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  10. 6530
    Cryo-EM structure of the sodium-driven chloride/bicarbonate exchanger NDCBE
    “...The mechanisms involved in SLC4-mediated ion transport are still under debate. Here, the authors...”
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  11. 6531
    The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation by promoting proteasomal degradation of NLRP3
    “... the ubiquitin-mediated proteasomal degradation of NLRP3, which may be a therapeutic target for alleviating...”
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  12. 6532
    Androgen receptor-binding sites are highly mutated in prostate cancer
    “...Androgen receptor (AR) mediated transcription is critical to prostate tumorigenesis and development...”
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  13. 6533
    Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
    “... glucose-mediated insulin secretion to reveal phosphorylation sites implicated in insulin secretion control...”
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  14. 6534
    Structural basis of substrate recognition and translocation by human ABCA4
    por Tian Xie, Zike Zhang, Qi Fang, Bowen Du, Xin Gong
    Publicado 2021
    “...-mediated lipid transport....”
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  15. 6535
    Candida albicans gains azole resistance by altering sphingolipid composition
    “.... present a piggyBac transposon-mediated mutagenesis system using stable haploid C. albicans strains...”
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  16. 6536
    Gene therapy for progressive familial intrahepatic cholestasis type 3 in a clinically relevant mouse model
    “...-associated virus mediated gene therapy prevents disease progression in a mouse disease model....”
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  17. 6537
    MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance
    “... of the presence of H2AX and is mediated through its PST-repeat region....”
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  18. 6538
    p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression
    “...AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity...”
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  19. 6539
    c-Met activation leads to the establishment of a TGFβ-receptor regulatory network in bladder cancer progression
    “... of MAPK and TGFβ pathways suppresses HGF-mediated bladder cancer progression....”
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  20. 6540
    Biogenic non-crystalline U(IV) revealed as major component in uranium ore deposits
    “... find that non-crystalline U(IV) generated through biologically mediated U(VI) reduction...”
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