Chromatin state changes during neural development revealed by in vivo cell-type specific profiling

por Owen J. Marshall, Andrea H. Brand
Publicado 2017

Comparison of the iLUX and the LipiFlow for the Treatment of Meibomian Gland Dysfunction and Symptoms: A Randomized Clinical Trial

por Tauber J, Owen J, Bloomenstein M, Hovanesian J, Bullimore MA
Publicado 2020

PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions

por Sonia T. Nicolaou, Max Hebditch, Owen J. Jonathan, Chandra S. Verma, Jim Warwicker
Publicado 2021

Functional exploration of colorectal cancer genomes using Drosophila

por Erdem Bangi, Claudio Murgia, Alexander G.S. Teague, Owen J. Sansom, Ross L. Cagan
Publicado 2016

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine.

por Boris Y Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B Pearson, Douglas J Winton, Owen J Sansom, Alan Ashworth, Alan R Clarke
Publicado 2009

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

por Christine Gundry, Sergi Marco, Elena Rainero, Bryan Miller, Emmanuel Dornier, Louise Mitchell, Patrick T. Caswell, Andrew D. Campbell, Anna Hogeweg, Owen J. Sansom, Jennifer P. Morton, Jim C. Norman
Publicado 2017

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap

por Anna Woroniuk, Andrew Porter, Gavin White, Daniel T. Newman, Zoi Diamantopoulou, Thomas Waring, Claire Rooney, Douglas Strathdee, Daniel J. Marston, Klaus M. Hahn, Owen J. Sansom, Tobias Zech, Angeliki Malliri
Publicado 2018

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

por David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Publicado 2019

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

por David M. Gay, Rachel A. Ridgway, Miryam Müller, Michael C. Hodder, Ann Hedley, William Clark, Joshua D. Leach, Rene Jackstadt, Colin Nixon, David J. Huels, Andrew D. Campbell, Thomas G. Bird, Owen J. Sansom
Publicado 2019

CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

por Louise van der Weyden, Victoria Harle, Gemma Turner, Victoria Offord, Vivek Iyer, Alastair Droop, Agnieszka Swiatkowska, Roy Rabbie, Andrew D. Campbell, Owen J. Sansom, Mercedes Pardo, Jyoti S. Choudhary, Ingrid Ferreira, Mark Tullett, Mark J. Arends, Anneliese O. Speak, David J. Adams
Publicado 2021

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal.

por Andrew J Muinonen-Martin, Olivia Susanto, Qifeng Zhang, Elizabeth Smethurst, William J Faller, Douwe M Veltman, Gabriela Kalna, Colin Lindsay, Dorothy C Bennett, Owen J Sansom, Robert Herd, Robert Jones, Laura M Machesky, Michael J O Wakelam, David A Knecht, Robert H Insall
Publicado 2014

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

por Gene I. Uenishi, Ho Sun Jung, Akhilesh Kumar, Mi Ae Park, Brandon K. Hadland, Ethan McLeod, Matthew Raymond, Oleg Moskvin, Catherine E. Zimmerman, Derek J. Theisen, Scott Swanson, Owen J. Tamplin, Leonard I. Zon, James A. Thomson, Irwin D. Bernstein, Igor I. Slukvin
Publicado 2018

Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade

por Sebastian R. Nielsen, Jan E. Strøbech, Edward R. Horton, Rene Jackstadt, Anu Laitala, Marina C. Bravo, Giorgia Maltese, Adina R. D. Jensen, Raphael Reuten, Maria Rafaeva, Saadia A. Karim, Chang-Il Hwang, Luis Arnes, David A. Tuveson, Owen J. Sansom, Jennifer P. Morton, Janine T. Erler
Publicado 2021

Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

por Andrea Sacchetti, Miriam Teeuwssen, Mathijs Verhagen, Rosalie Joosten, Tong Xu, Roberto Stabile, Berdine van der Steen, Martin M Watson, Alem Gusinac, Won Kyu Kim, Inge Ubink, Harmen JG Van de Werken, Arianna Fumagalli, Madelon Paauwe, Jacco Van Rheenen, Owen J Sansom, Onno Kranenburg, Riccardo Fodde
Publicado 2021

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

por Victoria Gudiño, Sebastian Öther-Gee Pohl, Caroline V. Billard, Patrizia Cammareri, Alfonso Bolado, Stuart Aitken, David Stevenson, Adam E. Hall, Mark Agostino, John Cassidy, Colin Nixon, Alex von Kriegsheim, Paz Freile, Linda Popplewell, George Dickson, Laura Murphy, Ann Wheeler, Malcolm Dunlop, Farhat Din, Douglas Strathdee, Owen J. Sansom, Kevin B. Myant
Publicado 2021

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

por Cheryl Q. E. Lee, Baptiste Kerouanton, Sonia Chothani, Shan Zhang, Ying Chen, Chinmay Kumar Mantri, Daniella Helena Hock, Radiance Lim, Rhea Nadkarni, Vinh Thang Huynh, Daryl Lim, Wei Leong Chew, Franklin L. Zhong, David Arthur Stroud, Sebastian Schafer, Vinay Tergaonkar, Ashley L. St John, Owen J. L. Rackham, Lena Ho
Publicado 2021

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

por Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas K. Hock, Nathalie Legrave, Oliver D. K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez-Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian S. W. Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden
Publicado 2021

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

por Amy S. Farrell, Meghan Morrison Joly, Brittany L. Allen-Petersen, Patrick J. Worth, Christian Lanciault, David Sauer, Jason Link, Carl Pelz, Laura M. Heiser, Jennifer P. Morton, Nathiya Muthalagu, Megan T. Hoffman, Sara L. Manning, Erica D. Pratt, Nicholas D. Kendsersky, Nkolika Egbukichi, Taylor S. Amery, Mary C. Thoma, Zina P. Jenny, Andrew D. Rhim, Daniel J. Murphy, Owen J. Sansom, Howard C. Crawford, Brett C. Sheppard, Rosalie C. Sears
Publicado 2017

The pathogenesis of mesothelioma is driven by a dysregulated translatome

por Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D. Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P. Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodósio, Catherine Ficken, Maria Guerra Martin, Ruth V. Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J. Sansom, Daniel Murphy, Marion MacFarlane, John P. C. Le Quesne, Anne E. Willis
Publicado 2021

WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

por Huimei Chen, Aida Moreno-Moral, Francesco Pesce, Nithya Devapragash, Massimiliano Mancini, Ee Ling Heng, Maxime Rotival, Prashant K. Srivastava, Nathan Harmston, Kirill Shkura, Owen J. L. Rackham, Wei-Ping Yu, Xi-Ming Sun, Nicole Gui Zhen Tee, Elisabeth Li Sa Tan, Paul J. R. Barton, Leanne E. Felkin, Enrique Lara-Pezzi, Gianni Angelini, Cristina Beltrami, Michal Pravenec, Sebastian Schafer, Leonardo Bottolo, Norbert Hubner, Costanza Emanueli, Stuart A. Cook, Enrico Petretto
Publicado 2019