Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application

by Christopher A. Kerantzas, William R. Jacobs
Published 2017

Postprimary Tuberculosis and Macrophage Necrosis: Is There a Big ConNECtion?

by Ka-Wing Wong, William R. Jacobs
Published 2016

A <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Cytochrome <italic toggle="yes">bd</italic> Oxidase Mutant Is Hypersensitive to Bedaquiline

by Michael Berney, Travis E. Hartman, William R. Jacobs
Published 2014

Sterilization by Adaptive Immunity of a Conditionally Persistent Mutant of Mycobacterium tuberculosis

by Catherine Vilchèze, Steven A. Porcelli, John Chan, William R. Jacobs
Published 2021

An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis.

by Anthony D Baughn, Scott J Garforth, Catherine Vilchèze, William R Jacobs
Published 2009

Essentiality of Succinate Dehydrogenase in <named-content content-type="genus-species">Mycobacterium smegmatis</named-content> and Its Role in the Generation of the Membrane Potent...

by Ildiko Pecsi, Kiel Hards, Nandula Ekanayaka, Michael Berney, Travis Hartman, William R. Jacobs, Gregory M. Cook
Published 2014

Acetic Acid, the Active Component of Vinegar, Is an Effective Tuberculocidal Disinfectant

by Claudia Cortesia, Catherine Vilchèze, Audrey Bernut, Whendy Contreras, Keyla Gómez, Jacobus de Waard, William R. Jacobs, Laurent Kremer, Howard Takiff
Published 2014

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> through Nutrien...

by Catherine Vilchèze, Jacqueline Copeland, Tracy L. Keiser, Torin Weisbrod, Jacqueline Washington, Paras Jain, Adel Malek, Brian Weinrick, William R. Jacobs
Published 2018

Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

by Dhinakaran Sambandan, Dee N. Dao, Brian C. Weinrick, Catherine Vilchèze, Sudagar S. Gurcha, Anil Ojha, Laurent Kremer, Gurdyal S. Besra, Graham F. Hatfull, William R. Jacobs
Published 2013

Malaria infections do not compromise vaccine-induced immunity against tuberculosis in mice.

by Marcela Parra, Steven C Derrick, Amy Yang, Jinhua Tian, Kristopher Kolibab, Miranda Oakley, Liyanage P Perera, William R Jacobs, Sanjai Kumar, Sheldon L Morris
Published 2011

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

by Álvaro Chiner-Oms, Michael Berney, Christine Boinett, Fernando González-Candelas, Douglas B. Young, Sebastien Gagneux, William R. Jacobs, Julian Parkhill, Teresa Cortes, Iñaki Comas
Published 2019

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

by Erik J. Hasenoehrl, Dannah Rae Sajorda, Linda Berney-Meyer, Samantha Johnson, JoAnn M. Tufariello, Tobias Fuhrer, Gregory M. Cook, William R. Jacobs, Michael Berney
Published 2019

Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.

by Dee N Dao, Kari Sweeney, Tsungda Hsu, Sudagar S Gurcha, Ivan P Nascimento, Ivan P Nascimento, Dan Roshevsky, Gurdyal S Besra, John Chan, Steven A Porcelli, William R Jacobs
Published 2008

Specialized Transduction Designed for Precise High-Throughput Unmarked Deletions in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

by Paras Jain, Tsungda Hsu, Masayoshi Arai, Karolin Biermann, David S. Thaler, Andrew Nguyen, Pablo A. González, Joann M. Tufariello, Jordan Kriakov, Bing Chen, Michelle H. Larsen, William R. Jacobs
Published 2014

Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.

by Katherine C Yam, Igor D'Angelo, Rainer Kalscheuer, Haizhong Zhu, Jian-Xin Wang, Victor Snieckus, Lan H Ly, Paul J Converse, William R Jacobs, Natalie Strynadka, Lindsay D Eltis
Published 2009

Enhanced Specialized Transduction Using Recombineering in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

by JoAnn M. Tufariello, Adel A. Malek, Catherine Vilchèze, Laura E. Cole, Hannah K. Ratner, Pablo A. González, Paras Jain, Graham F. Hatfull, Michelle H. Larsen, William R. Jacobs
Published 2014

Dual-Reporter Mycobacteriophages (Φ²DRMs) Reveal Preexisting <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Persistent Cells in H...

by Paras Jain, Brian C. Weinrick, Eric J. Kalivoda, Hui Yang, Vanisha Munsamy, Catherine Vilcheze, Torin R. Weisbrod, Michelle H. Larsen, Max R. O’Donnell, Alexander Pym, William R. Jacobs
Published 2016

Targeting <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antitubercu...

by Aaron Olsen, Yong Chen, Qingzhou Ji, Guofeng Zhu, Aruna Dharshan De Silva, Catherine Vilchèze, Torin Weisbrod, Weimin Li, Jiayong Xu, Michelle Larsen, Jinghang Zhang, Steven A. Porcelli, William R. Jacobs, John Chan
Published 2016

Genomics and Proteomics of Mycobacteriophage Patience, an Accidental Tourist in the <italic toggle="yes">Mycobacterium</italic> Neighborhood

by Welkin H. Pope, Deborah Jacobs-Sera, Daniel A. Russell, Daniel H. F. Rubin, Afsana Kajee, Zama N. P. Msibi, Michelle H. Larsen, William R. Jacobs, Jeffrey G. Lawrence, Roger W. Hendrix, Graham F. Hatfull
Published 2014

A Nonribosomal Peptide Synthase Gene Driving Virulence in <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content>

by Kiranmai Bhatt, Henrique Machado, Nuno S. Osório, Jeremy Sousa, Filipa Cardoso, Carlos Magalhães, Bing Chen, Mei Chen, John Kim, Albel Singh, Catarina M. Ferreira, António G. Castro, Egidio Torrado, William R. Jacobs, Apoorva Bhatt, Margarida Saraiva
Published 2018