Replication pauses of the wild-type and mutant mitochondrial DNA polymerase gamma: a simulation study.

The activity of polymerase γ is complicated, involving both correct and incorrect DNA polymerization events, exonuclease activity, and the disassociation of the polymerase:DNA complex. Pausing of pol-γ might increase the chance of deletion and depletion of mitochondrial DNA. We have developed a stoc...

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Autores principales: Zhuo Song, Yang Cao, David C Samuels
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/8611fe1b6c224399a07f61abcf58b80d
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