Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes
Plasticity and clonal population structure in bacterial genomes can hinder traditional SNP-based genetic association studies. Here, Corander and colleagues present a method to identify variable-length sequence elements enriched in a phenotype of interest, and demonstrate its use in human pathogens.
Enregistré dans:
Auteurs principaux: | John A. Lees, Minna Vehkala, Niko Välimäki, Simon R. Harris, Claire Chewapreecha, Nicholas J. Croucher, Pekka Marttinen, Mark R. Davies, Andrew C. Steer, Steven Y. C. Tong, Antti Honkela, Julian Parkhill, Stephen D. Bentley, Jukka Corander |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2016
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/cf0152cd3fa84f69ab1a6244a1daed1f |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Improved Prediction of Bacterial Genotype-Phenotype Associations Using Interpretable Pangenome-Spanning Regressions
par: John A. Lees, et autres
Publié: (2020) -
Corrigendum: An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
par: Chalita Chomkatekaew, et autres
Publié: (2021) -
An Evolutionary Arms Race Between Burkholderia pseudomallei and Host Immune System: What Do We Know?
par: Chalita Chomkatekaew, et autres
Publié: (2021) -
Publisher Correction: Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis
par: Lucy A. Weinert, et autres
Publié: (2019) -
Diversification of Colonization Factors in a Multidrug-Resistant <named-content content-type="genus-species">Escherichia coli</named-content> Lineage Evolving under Negative Frequency-Dependent Selection
par: Alan McNally, et autres
Publié: (2019)