Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence

Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence

Abstract Streptococcus mutans employs a key virulence factor, three glucosyltransferase (GtfBCD) enzymes to establish cariogenic biofilms. Therefore, the inhibition of GtfBCD would provide anti-virulence therapeutics. Here a small molecule library of 500,000 small molecule compounds was screened in...

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Autores principales: Qiong Zhang, Bhavitavya Nijampatnam, Zhang Hua, Thao Nguyen, Jing Zou, Xia Cai, Suzanne M. Michalek, Sadanandan E. Velu, Hui Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/fd06f20a37b34ee2a6b0c326fa712604
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