ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent toxic DNA end-joining leading to chromosome fusion...

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Autores principales:	Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C. Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T. Durant, Yaron Galanty, Petra Beli, David J. Adams, Allan Bradley, Emmanouil Metzakopian, Josep V. Forment, Stephen P. Jackson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c403db6b24d849f3aa73ce7778708c4a
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spelling	oai:doaj.org-article:c403db6b24d849f3aa73ce7778708c4a2021-12-02T17:01:31ZATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks10.1038/s41467-018-07729-22041-1723https://doaj.org/article/c403db6b24d849f3aa73ce7778708c4a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07729-2https://doaj.org/toc/2041-1723Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent toxic DNA end-joining leading to chromosome fusions and cell death.Gabriel BalmusDomenic PilgerJulia CoatesMukerrem DemirMatylda Sczaniecka-CliftAna C. BarrosMichael WoodsBeiyuan FuFengtang YangElisabeth ChenMatthias OstermaierTatjana StankovicHannes PonstinglMareike HerzogKosuke YusaFrancisco Munoz MartinezStephen T. DurantYaron GalantyPetra BeliDavid J. AdamsAllan BradleyEmmanouil MetzakopianJosep V. FormentStephen P. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gabriel Balmus Domenic Pilger Julia Coates Mukerrem Demir Matylda Sczaniecka-Clift Ana C. Barros Michael Woods Beiyuan Fu Fengtang Yang Elisabeth Chen Matthias Ostermaier Tatjana Stankovic Hannes Ponstingl Mareike Herzog Kosuke Yusa Francisco Munoz Martinez Stephen T. Durant Yaron Galanty Petra Beli David J. Adams Allan Bradley Emmanouil Metzakopian Josep V. Forment Stephen P. Jackson ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
description	Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging chemotherapeutic agents. Here, the authors provide evidence that these hypersensitivities reflect a crucial role for ATM at damaged replication forks being to prevent toxic DNA end-joining leading to chromosome fusions and cell death.
format	article
author	Gabriel Balmus Domenic Pilger Julia Coates Mukerrem Demir Matylda Sczaniecka-Clift Ana C. Barros Michael Woods Beiyuan Fu Fengtang Yang Elisabeth Chen Matthias Ostermaier Tatjana Stankovic Hannes Ponstingl Mareike Herzog Kosuke Yusa Francisco Munoz Martinez Stephen T. Durant Yaron Galanty Petra Beli David J. Adams Allan Bradley Emmanouil Metzakopian Josep V. Forment Stephen P. Jackson
author_facet	Gabriel Balmus Domenic Pilger Julia Coates Mukerrem Demir Matylda Sczaniecka-Clift Ana C. Barros Michael Woods Beiyuan Fu Fengtang Yang Elisabeth Chen Matthias Ostermaier Tatjana Stankovic Hannes Ponstingl Mareike Herzog Kosuke Yusa Francisco Munoz Martinez Stephen T. Durant Yaron Galanty Petra Beli David J. Adams Allan Bradley Emmanouil Metzakopian Josep V. Forment Stephen P. Jackson
author_sort	Gabriel Balmus
title	ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
title_short	ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
title_full	ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
title_fullStr	ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
title_full_unstemmed	ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
title_sort	atm orchestrates the dna-damage response to counter toxic non-homologous end-joining at broken replication forks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c403db6b24d849f3aa73ce7778708c4a
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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

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